Exacerbating and reversing lysosomal storage diseases: from yeast to humans
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چکیده
منابع مشابه
Exacerbating and reversing lysosomal storage diseases: from yeast to humans
Lysosomal storage diseases (LSDs) arise from monogenic deficiencies in lysosomal proteins and pathways and are characterized by a tissue-wide accumulation of a vast variety of macromolecules, normally specific to each genetic lesion. Strategies for treatment of LSDs commonly depend on reduction of the offending metabolite(s) by substrate depletion or enzyme replacement. However, at least 44 of ...
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ژورنال
عنوان ژورنال: Microbial Cell
سال: 2017
ISSN: 2311-2638
DOI: 10.15698/mic2017.09.588